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  Zanco J Med Sci:  Apr. 2018; 22 (1): 32-40

The role of some oxidative stress and inflammatory factors in essential hypertension

Julian Yonan Ismaeil *, Shatha Rouf Moustafa **


* Directorate of Health, Erbil, Iraq.

** Department of Clinical Biochemistry, College of Pharmacy, Hawler Medical University, Erbil, Iraq.


Background and Objective: Oxidative stress and inflammation are cooperative events involved in essential hypertension development. This study aimed to evaluate the association of N-terminal pro-Brain natriuretic peptide, matrix-metalloprotinase-9 and 8-oxo2-deoxyguanosine with the essential hypertension, detect the effect of other confounding factors like the stage of the disease and gender, and estimate the correlation between the selected parameters.

Methods: This case-control study was performed at College of Pharmacy, Hawler Medical University on 50 hypertensive patients of both genders with essential hypertension as well as 45 matched age–gender adults were also enrolled in this study as a control group. The selected parameters were analyzed using ELISA technique.

Results: There was a significant elevation in the serum levels of N-terminal pro-Brain natriuretic peptide, matrix-metalloprotinase-9 and 8-oxo2-deoxyguanosine in patients with essential hypertension as compared with the controls. The mean serum levels N-terminal pro-Brain natriuretic peptide, matrix-metalloprotinase-9 and 8-oxo2-deoxyguanosine were increased significantly according to the stage progression of the disease P ˂0.001. No gender effects could be found. 

Conclusion: Data suggested an association between circulating biomarkers (NT-proBNP, MMP -9, 8-oxo-2-dG) with the development of essential hypertension, there was a significant elevations in the serum selected parameters level in patients as compared with the control group.

Keywords: EHT; NT-proBNP; MMP -9; 8-oxo-2-dG.



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