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  Zanko J Med Sci:  Dec. 2017; 21 (3): 1829-1839

Oxidative stress in relation to two different pathologies in metabolic syndrome patients

Sanaa Gadbaan Hama *, Ava Tahir Ismaeel *, Showan Dawood Hussain *


* Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Iraq.


Background and objective: Little is known about the status of redox balance and hypertensive nondiabetic and diabetic nonhypertensive metabolic syndrome patients and its relation to metabolic syndrome components in both pathological conditions. This study aimed to assess the association of redox balance with components of metabolic syndrome in "diabetic and hypertensive, metabolic syndrome" patients to find out which pathology can give a powerful evidence for a possible association with oxidative stress.

Methods: The total oxidative capacity, total antioxidant capacity, lipid profile and fasting serum glucose were measured in serum of 35 healthy subjects, 33 hypertensive nondiabetic and 21 diabetic nonhypertensive, metabolic syndrome patients. The body mass index and waist circumference were also measured. All groups were age and gender matched.

Results: In stratified groups, the highly significant total oxidative capacity, total antioxidant capacity and oxidative stress index were shown in diabetic and hypertensive groups respectively compared with healthy control group, with no significant effect for diabetes on total oxidative capacity and oxidative stress index compared to hypertension condition.

Conclusion: Although the presence of significant higher total oxidative capacity in both study pathologies compared to healthy control, however among metabolic syndrome patients neither hypertension nor diabetes mellitus achieved more dominant to total oxidative capacity. 

Keywords: Metabolic syndrome; Total oxidative capacity; Total antioxidant capacity.


1. Bandeira SM, Pires AS , Guedes GS, Gelain DP, Mary S L, Fonseca LJ, et al.'Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity,. Oxidative Medicine and Cellular Longevity 2012; (1):1-14.

2. Wild SH, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27:1047-53. 

3. Dandu AM, Inamdar NM. Evaluation of beneficial effect of antioxidant properties of some plants in diabetic rats. Pak J pharma Sci2009; 22(1):49-52.

 4. Khan AN, Khan RA, Ahmad M, Mushtaq N. Role of antioxidant in oxidative stress and diabetes Mellitus. Journal of Pharmacognosy and Phytochemistry 2015; 3(6):217-20.

5. Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arteriosclerosis, Thrombosis, and Vascular Biology 2004; 24(5):816-23.

6. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine.4th ed. New York, NY, USA:Oxford University Press; 2007.

7. Negre SA, Salvayre R, Auge N, Pamplona R, Porterot M. Hyperglycemia and glycation in diabetic complications. Antioxidants and Redox Signaling 2009; 11(12):3071-109.

8. Baradaran A, Nasri H, Kopae MR. Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants. J Res Med Sci 2014; 19(4):358-67.

9. Zicha J, Dobesova Z, Kunes J. Relative deficiency of nitric oxide−dependent vasodilation in salt-hypertensive Dahl rats: the possible role of superoxide anions. J Hypertens 2001; 19:247–54.

10. Mahjoub S, Masrour Roudsari J. Role of oxidative stress in pathogenesis of metabolic syndrome. Caspian J Intern Med 2014; 3 (1):386-96.

11. Crook MA. Clinical chemistry and metabolic medicine. 7thed.338 Euston Road, London: Hodder Arnold; 2006. P. 174-97.

12. Sullivan GM , Feinn R. Using Effect Size—or Why the P Value Is Not Enough. J Grad Med Educ 2012; 4 (3): 279-82.

13. Kim CH, Younossi ZM. Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome. Cleve Clin J Med 2008; 75:721-8.

14. Eschwege E. The dysmetabolic syndrome, insulin resistance and increased cardiovascular (CV) morbidity and mortality in type 2 diabetes: aetiological factors in the development of CV complications. Diabetes Metab 2003: 29; 6S19-27.

15. Rosen P, Nawroth PP, King G, Moller W, Tritschler HJ, Packer L. The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab Res Rev2001; 17:189-212.

16. Senti M, Tomas M, Fito M, Weinbrenner T, Covas MI, Sala J, et al. Antioxidant paraoxonase 1 activity inthe metabolic syndrome. J Clin Endocrinol Metab 2003; 88:5422-6.

17. Taheri E, Djalali M, Saedisomeolia A, Moghadam AM, Djazayeri A. The relationship between the activates of antioxidant enzymes in red blood cells and bodymass index in Iranian type 2 diabetes and healthy subjects. J Diabetes Metabolic Disorders 2012; 11(3):1-5.

18. Janiszewski PM, Janssen I, Ross R. “Does waist circumference predict diabetes and cardiovascular disease beyondcommonly evaluated cardiometabolic risk factors?”. Diabetes Care 2007; 30: 3105– 9.

19. Archivio MD ,Annuzzi G,Varı R . “Predominant role of obesity/insulin resistance in oxidative stress development,”. Europ J Clin Invest 2012; 42 (1):70-8.

20. Urakawa H, Katsuki A, Sumida Y. “Oxidative stress is associated with adiposity and insulin resistance in men,” . J ClinEndocrinol Metab 2003; 88 (10):4673-6.

21. Tabur S, Nur-Torun T, Suzan-Tabur NA, Nur-Torun A, Aksoy N, Sabuncu T, et al. Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation. Europ JEndocrinol 2010; 162:535-41.

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